Portal de investigación
Low Muscle Mass Is Associated with Poorer Glycemic Control and Higher Oxidative Stress in Older Patients with Type 2 Diabetes
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- De la Rosa, A
Grupos y Plataformas de I+D+i
Abstract
Body composition changes that occur during aging, such as loss of lean mass, are unfavorable at metabolic level and they can explain, in part, the appearance of certain age-associated diseases such as type 2 diabetes (T2D). Separately, T2D is associated with an increase in oxidative stress (OS) which negatively affects skeletal muscle. Our aim was to study the differences in clinical and nutritional parameters, disease control, and OS in a cohort of older patients with T2D classified according to the amount of lean mass they had. We included 100 adults older than 65 years with T2D. We found that women with low fat-free mass and muscle mass have worse T2D metabolic control. Moreover, the patients with a low percentile of muscle mass present a high value of OS. The study shows that the presence of low lean mass (LM) in the geriatric population diagnosed with T2D is associated with poorer glycemic control and greater OS.
Datos de la publicación
- ISSN/ISSNe:
- 2072-6643, 2072-6643
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/nu15143167
- PubMed:
- 37513585
Nutrients MDPI AG
Citas Recibidas en Web of Science: 11
Documentos
Filiaciones
Keywords
- muscle mass; diabetes; aging; body composition; oxidative stress
Financiación
Proyectos y Estudios Clínicos
'Una aproximación translacional desde la clínica a la experimentación animal: Estudio del papel del eje CCL11/CCR3 y la inflamación eosinofílica en la patología cardiovascular asociada a desórdenes metabólicos. -
Investigador Principal: MARIA JESUS SANZ FERRANDO
PROMETEO2019/032 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2020
Cita
Alabadi B,Civera M,De la Rosa A,Martinez S,Gomez MC,Real JT. Low Muscle Mass Is Associated with Poorer Glycemic Control and Higher Oxidative Stress in Older Patients with Type 2 Diabetes. Nutrients. 2023. 15. (14):3167. IF:4,800. (1).
Low Muscle Mass Is Associated with Poorer Glycemic Control and Higher Oxidative Stress in Older Patients with Type 2 Diabetes. Alabadi B, Civera M, De la Rosa A, Martinez S, Gomez MC, Real JT. Nutrients. 2023 julio 01. 15 (14):DOI:10.3390/nu15143167. PMID:37513585.
