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Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure.

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Autores de INCLIVA

Participantes ajenos a INCLIVA

  • Amiguet, M
  • Rodriguez, JC
  • Moyano, P
  • Segarra, D
  • Fernandez, J
  • Nunez, G
  • Alania, E
  • Valle, A
  • Codina, P
  • Voors, AA
  • Bayes-Genis, A

Grupos y Plataformas de I+D+i

Abstract

AIMS: Bendopnea is a clinical symptom of advanced heart failure with uncertain prognostic value. We aimed to evaluate whether bendopnea and the change in oxygen saturation when bending forward (bending oxygen saturation index [BOSI]) are associated with adverse outcomes in ambulatory chronic heart failure (CHF) patients. METHODS AND RESULTS: We prospectively evaluated 440 subjects with symptomatic CHF. BOSI was defined as the difference between sitting and bending oxygen saturation (SpO(2) ). The endpoint was the total number of worsening heart failure (WHF) events (heart failure hospitalization or urgent heart failure visit requiring parenteral diuretic therapy). The mean age was 74 ± 10 years, 257 (58.6%) were male, and 226 (51.4%) had a left ventricular ejection fraction <50%. Bendopnea was present in 94 (21.4%) patients, and 120 (27.3%) patients had a BOSI =-3%. The agreement between BOSI =-3% and bendopnea was moderate (Gwet's AC 0.482, p < 0.001). At a median (p25%-p75%) follow-up of 2.17 years (0.88-3.16), we registered 441 WHF events in 148 patients. After multivariable adjustment, BOSI was independently associated with the risk for total WHF episodes (overall, p < 0.001). Compared to improvement/no change in SpO(2) when bending (BOSI 0%), those with BOSI =-3% showed an increased risk of WHF events (incidence rate ratio [IRR] 2.16, 95% confidence interval [CI] 1.67-2.79; p < 0.001). In contrast, bendopnea was not associated with the risk of total WHF episodes (IRR 1.04, 95% CI 0.83-1.31; p = 0.705). CONCLUSIONS: In ambulatory and stable CHF patients, BOSI =-3% and not bendopnea was independently associated with an increased risk of total (first and recurrent) WHF episodes. Awareness of SpO(2) while assessing bendopnea may be a useful tool for predicting heart failure decompensations.

© 2022 European Society of Cardiology.

Datos de la publicación

ISSN/ISSNe:
1388-9842, 1879-0844

EUROPEAN JOURNAL OF HEART FAILURE  WILEY

Tipo:
Article
Páginas:
2108-2117
PubMed:
36054502

Citas Recibidas en Web of Science: 7

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Keywords

  • Arterial oxygen desaturation; Bendopnea; Outcome; Worsening heart failure

Campos de Estudio

Financiación

CIBER Cardiovascular (16/11/00403)
CIBER Cardiovascular (16/11/00420)
INSTITUTO SALUD CARLOS III (CB16/11/00420)
INSTITUTO SALUD CARLOS III (PI20/00392)
Ministry of Economy and Competitiveness

Proyectos y Estudios Clínicos

INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER

Investigador Principal: JUAN SANCHIS FORES

CB16/11/00420 . INSTITUTO SALUD CARLOS III

Congestión Renal en Insuficiencia Cardiaca Aguda y Síndrome Cardiorenal: Valoración No Invasiva Mediante Doppler Vascular Renal

Investigador Principal: JULIO NUÑEZ VILLOTA

PI20/00392 . INSTITUTO SALUD CARLOS III . 2021

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