Portal de investigación
Incidence, Treatment and Clinical Impact of Iron Deficiency in Chronic Heart Failure: A Longitudinal Analysis.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Ramirez de Arellano, Antonio
- Wachter, Sandra
- Nunez, Eduardo
- Bayes-Genis, Antoni
Grupos y Plataformas de I+D+i
Abstract
In patients with heart failure (HF), iron deficiency (ID) is a well-recognized therapeutic target; information about its incidence, patterns of iron repletion, and clinical impact is scarce. This single-centre longitudinal cohort study assessed the rates of ID testing and diagnosis in patients with stable HF, patterns of treatment with intravenous iron, and clinical impact of intravenous iron on HF rehospitalization risk. We included 711 consecutive outpatients (4400 visits) with stable chronic HF from 2014 to 2019 (median [interquartile range] visits per patient: 2 [2-7]. ID was defined as serum ferritin <100 µg/L, or 100-299 µg/L with transferrin saturation (TSAT) < 20%. During a median follow-up of 2.20 (1.11-3.78) years, ferritin and TSAT were measured at 2230 (50.7%) and 2183 visits (49.6%), respectively. ID was found at 846 (37.9%) visits, with ferritin and TSAT available (2230/4400), and intravenous iron was administered at 321/4400 (7.3%) visits; 233 (32.8%) patients received intravenous iron during follow-up. After multivariate analyses, iron repletion at any time during follow-up was associated with a lower risk of recurrent HF hospitalization (hazard ratio [HR] = 0.50, 95% confidence interval [CI] = 0.28-0.88; p = 0.016). Thus, ID was a frequent finding in patients with HF, and its repletion reduced the risk of recurrent HF hospitalizations.
Datos de la publicación
- ISSN/ISSNe:
- 2077-0383, 2077-0383
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/jcm11092559
- PubMed:
- 35566684
Journal of Clinical Medicine MDPI
Citas Recibidas en Web of Science: 1
Documentos
Filiaciones
Keywords
- heart failure; iron deficiency; prevalence; treatment
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Cita
Minana G,Lorenzo M,Ramirez de Arellano A,Wachter S,de la Espriella R,Sastre C,Mollar A,Nunez E,Bodi V,Sanchis J,Bayes A,Nunez J. Incidence, Treatment and Clinical Impact of Iron Deficiency in Chronic Heart Failure: A Longitudinal Analysis. J. Clin. Med. 2022. 11. (9):2559. IF:3,900. (2).
Incidence, Treatment and Clinical Impact of Iron Deficiency in Chronic Heart Failure: A Longitudinal Analysis. Minana G, Lorenzo M, Ramirez de Arellano A, Wachter S, de la Espriella R, Sastre C, Mollar A et al. Journal of Clinical Medicine. 2022 mayo 02. 11 (9):DOI:10.3390/jcm11092559. PMID:35566684.
