Portal de investigación
Risk score for early risk prediction by cardiac magnetic resonance after acute myocardial infarction.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Perez, Nerea
- Gavara, Jose
- Lopez-Lereu, Maria P
- Monmeneu, Jose V
- Moratal, David
- Valente, Filipa
- Lorenzatti, Daniel
- Ortiz-Perez, Jose T
- Rodriguez-Palomares, Jose F
Grupos y Plataformas de I+D+i
Abstract
BACKGROUND: Cardiac magnetic resonance (CMR) performed early after ST-segment elevation myocardial infarction (STEMI) can improve major adverse cardiac event (MACE) risk prediction. We aimed to create a simple clinical-CMR risk score for early MACE risk stratification in STEMI patients. METHODS: We performed a multicenter prospective registry of reperfused STEMI patients (n = 1118) in whom early (1-week) CMR-derived left ventricular ejection fraction (LVEF), infarct size and microvascular obstruction (MVO) were quantified. MACE was defined as a combined clinical endpoint of cardiovascular (CV) death, non-fatal myocardial infarction (NF-MI) or re-admission for acute decompensated heart failure (HF). RESULTS: During a median follow-up of 5.52 [2.63-7.44] years, 216 first MACE (58 CV deaths, 71 NF-MI and 87 HF) were registered. Mean age was 59.3 ± 12.3 years and most patients (82.8%) were male. Based on the four variables independently associated with MACE, we computed an 8-point risk score: time to reperfusion >4.15 h (1 point), GRACE risk score > 155 (3 points), CMR-LVEF <40% (3 points), and MVO >1.5 segments (1 point). This score permitted MACE risk stratification: MACE per 100 person-years was 1.96 in the low-risk category (0-2 points), 5.44 in the intermediate-risk category (3-5 points), and 19.7 in the high-risk category (6-8 points): p < 0.001 in multivariable Cox survival analysis. CONCLUSIONS: A novel risk score including clinical (time to reperfusion >4.15 h and GRACE risk score > 155) and CMR (LVEF <40% and MVO >1.5 segments) variables allows for simple and straightforward MACE risk stratification early after STEMI. External validation should confirm the applicability of the risk score.
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0167-5273, 1874-1754
- Tipo:
- Article
- Páginas:
- 150-154
- PubMed:
- 34826497
INTERNATIONAL JOURNAL OF CARDIOLOGY ELSEVIER IRELAND LTD
Citas Recibidas en Web of Science: 12
Documentos
Filiaciones
Keywords
- Cardiac magnetic resonance; Left ventricular ejection fraction; Microvascular obstruction; Myocardial infarction; Prognosis; Risk
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: VICENT BODÍ PERIS
CB16/11/00486 . INSTITUTO SALUD CARLOS III
Resolution of microvascular obstruction after myocardial infarction. A multidisciplinary approach to assess the structural and clinical consequences and to evaluate new therapeutic options.
Investigador Principal: VICENT BODÍ PERIS
PI20/00637 . INSTITUTO SALUD CARLOS III . 2021
AYUDAS JUAN DE LA CIERVA INCORPORACIÓN 2020
Investigador Principal: ANA MARÍA ORTEGA GUTIÉRREZ
IJC2020-045308-I . MINISTERIO DE CIENCIA E INNOVACIÓN . 2022
Cita
Marcos V,Perez N,Gavara J,Lopez MP,Monmeneu JV,Rios C,de Dios E,Merenciano H,Gabaldon A,Canoves J,Racugno P,Bonanad C,Minana G,Nunez J,Moratal D,Chorro FJ,Valente F,Lorenzatti D,Ortiz JT,Rodriguez JF,Bodi V. Risk score for early risk prediction by cardiac magnetic resonance after acute myocardial infarction. Int. J. Cardiol. 2022. 349. p. 150-154. IF:3,500. (2).
Risk score for early risk prediction by cardiac magnetic resonance after acute myocardial infarction. Marcos V, Perez N, Gavara J, Lopez MP, Monmeneu JV, Rios C, de Dios E et al. INTERNATIONAL JOURNAL OF CARDIOLOGY. 2022 febrero 15. 349150-154. DOI:10.1016/j.ijcard.2021.11.050. PMID:34826497.
