Portal de investigación
CA125 but not NT-proBNP predicts the presence of a congestive intrarenal venous flow in patients with acute heart failure.
Fecha de publicación:
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Autores de INCLIVA
Participantes ajenos a INCLIVA
- Nunez, E
- Bayes-Genis, A
Grupos y Plataformas de I+D+i
Abstract
BACKGROUND: Intrarenal venous flow (IRVF) measured by Doppler ultrasound has gained interest as a potential surrogate marker of renal congestion and adverse outcomes in heart failure. In this work, we aimed to determine if antigen carbohydrate 125 (CA125) and plasma amino-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated with congestive IRVF patterns (i.e., biphasic and monophasic) in acute heart failure (AHF). METHODS AND RESULTS: We prospectively enrolled a consecutive cohort of 70 patients hospitalized for AHF. Renal Doppler ultrasound was assessed within the first 24-h of hospital admission. The mean age of the sample was 73.5 ± 12.3 years; 47.1% were female, and 42.9% exhibited heart failure with preserved ejection fraction. The median (interquartile range) for NT-proBNP and CA125 were 6149 (3604-12 330) pg/mL and 64 (37-122) U/mL, respectively. The diagnostic performance of both exposures for identifying congestive IRVF patterns was tested using the receiving operating curve (ROC). The cut-off for CA125 of 63.5 U/mL showed a sensibility and specificity of 67% and 74% and an area under the ROC curve of 0.71. After multivariate adjustment, CA125 remained non-linearly and positively associated with congestive IRVF (P-value = 0.008) and emerged as the most important covariate explaining the variability of the model (R2: 47.5%). Under the same multivariate setting, NT-proBNP did not show to be associated with congestive IRVF patterns (P-value = 0.847). CONCLUSIONS: CA125 and not NT-proBNP is a useful marker for identifying patients with AHF and congestive IRVF patterns.
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.
Datos de la publicación
- ISSN/ISSNe:
- 2048-8726, 2048-8734
- Tipo:
- Article
- Páginas:
- 475-483
- PubMed:
- 33829233
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE SAGE PUBLICATIONS LTD
Citas Recibidas en Web of Science: 30
Documentos
Filiaciones
Keywords
- Acute heart failure; Biomarkers; CA125; Cardiorenal; Congestion; Intrarrenal Doppler ultrasound; NTproBNP
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Congestión Renal en Insuficiencia Cardiaca Aguda y Síndrome Cardiorenal: Valoración No Invasiva Mediante Doppler Vascular Renal
Investigador Principal: JULIO NUÑEZ VILLOTA
PI20/00392 . INSTITUTO SALUD CARLOS III . 2021
Cita
Nunez G,de la Espriella R,Santas E,Lorenzo M,Minana G,Nunez E,Bodi V,Gonzalez M,Gorriz JL,Bonanad C,Sanchis J,Bayes A,Nunez J. CA125 but not NT-proBNP predicts the presence of a congestive intrarenal venous flow in patients with acute heart failure. Eur. Heart J.-Acute Cardiovasc. Care. 2021. 10. (5):p. 475-483. IF:4,766. (2).
CA125 but not NT-proBNP predicts the presence of a congestive intrarenal venous flow in patients with acute heart failure. Nunez G, de la Espriella R, Santas E, Lorenzo M, Minana G, Nunez E, Bodi V et al. EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE. 2021 junio 30. 10 (5):475-483. DOI:10.1093/ehjacc/zuab022. PMID:33829233.
