Portal de investigación
Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Diez-Villanueva, Pablo
- Garcia-Acuna, Jose Maria
- Raposeiras-Roubin, Sergio
- Barrabes, Jose A
- Cordero, Alberto
- Martinez-Selles, Manuel
- Bardaji, Alfredo
- Marin, Francisco
- Ruiz-Nodar, Juan M
- Vicente-Ibarra, Nuria
- Alonso Salinas, Gonzalo L
- Cid-Alvarez, Belen
- Abu Assi, Emad
- Formiga, Frances
- Nunez, Eduardo
- Ariza-Sole, Albert
Grupos y Plataformas de I+D+i
Abstract
Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged =70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18-1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84-1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men.
Datos de la publicación
- ISSN/ISSNe:
- 2077-0383, 2077-0383
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/jcm10194403
- PubMed:
- 34640420
Journal of Clinical Medicine MDPI
Citas Recibidas en Web of Science: 7
Documentos
Filiaciones
Keywords
- diabetes mellitus; elderly; non-ST-segment elevation acute coronary syndromes; women
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Cita
Diez P,Garcia JM,Raposeiras S,Barrabes JA,Cordero A,Martinez M,Bardaji A,Marin F,Ruiz JM,Vicente N,Alonso GL,Cid B,Abu E,Formiga F,Nunez J,Nunez E,Ariza A,Sanchis J. Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome. J. Clin. Med. 2021. 10. (19):4403. IF:4,964. (2).
Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome. Diez P, Garcia JM, Raposeiras S, Barrabes JA, Cordero A, Martinez M, Bardaji A et al. Journal of Clinical Medicine. 2021 septiembre 26. 10 (19):DOI:10.3390/jcm10194403. PMID:34640420.
