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Immunometabolism Modulation in Therapy.

Fecha de publicación: Fecha Ahead of Print:

Autores de INCLIVA

Participantes ajenos a INCLIVA

  • Farinas, F
  • Villatoro, A
  • Abanades, S
  • Manes, S
  • de la Cruz-merino, L
  • Naranjo, TA

Grupos y Plataformas de I+D+i

Abstract

The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importance on immune system cells. Enhanced understanding of the molecular bases that give rise to alterations of pathways related to tumor development can open up new therapeutic intervention opportunities, such as metabolic regulation applied to immunotherapy. This review outlines the role of various oncometabolites and immunometabolites, such as TCA intermediates, in shaping pro/anti-inflammatory activity of immune cells such as MDSCs, T lymphocytes, TAMs and DCs in cancer. We also discuss the extraordinary plasticity of the immune response and its implication in immunotherapy efficacy, and highlight different therapeutic intervention possibilities based on controlling the balanced systems of specific metabolites with antagonistic functions.

Datos de la publicación

ISSN/ISSNe:
2227-9059, 2227-9059

Biomedicines  MDPI AG

Tipo:
Article
Páginas:
-
PubMed:
34356862

Citas Recibidas en Web of Science: 10

Documentos

Métricas

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Keywords

  • immunometabolites; metabolic reprogramming; oncometabolites; regulatory balance

Campos de Estudio

Financiación

INSTITUTO SALUD CARLOS III (PI20/01107)

Proyectos y Estudios Clínicos

Neuroblastoma: estrategias mecanoterapéuticas basadas en modelos 3D y tumores derivados de pacientes con microambiente rico en vitronectina

Investigador Principal: ROSA NOGUERA SALVA

PI20/01107 . INSTITUTO SALUD CARLOS III . 2021

Cita

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