Portal de investigación
EpCAM and microvascular obstruction in patients with STEMI: a cardiac magnetic resonance study.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Gavara, Jose
- Revuelta-Lopez, Elena
- Monmeneu, Jose V
- Lopez-Lereu, Maria P
- Perez-Sole, Nerea
- Bayes-Genis, Antoni
Grupos y Plataformas de I+D+i
Abstract
INTRODUCTION AND OBJECTIVES: Microvascular obstruction (MVO) is negatively associated with cardiac structure and worse prognosis after ST-segment elevation myocardial infarction (STEMI). Epithelial cell adhesion molecule (EpCAM), involved in epithelium adhesion, is an understudied area in the MVO setting. We aimed to determine whether EpCAM is associated with the appearance of cardiac magnetic resonance (CMR)-derived MVO and long-term systolic function in reperfused STEMI. METHODS: We prospectively included 106 patients with a first STEMI treated with percutaneous coronary intervention, quantifying serum levels of EpCAM 24hours postreperfusion. All patients underwent CMR imaging 1 week and 6 months post-STEMI. The independent correlation of EpCAM with MVO, systolic volume indices, and left ventricular ejection fraction was evaluated. RESULTS: The mean age of the sample was 59±13 years and 76% were male. Patients were dichotomized according to median EpCAM (4.48 pg/mL). At 1-week CMR, lower EpCAM was related to extensive MVO (P=.021) and larger infarct size (P=.019). At presentation, EpCAM values were significantly associated with the presence of MVO in univariate (OR, 0.58; 95%CI, 0.38-0.88; P=.011) and multivariate logistic regression models (OR, 0.55; 95%CI, 0.35-0.87; P=.010). Although MVO tends to resolve at chronic phases, decreased EpCAM was associated with worse systolic function: reduced left ventricular ejection fraction (P=.009) and higher left ventricular end-systolic volume (P=.043). CONCLUSIONS: EpCAM is associated with the occurrence of CMR-derived MVO at acute phases and long-term adverse ventricular remodeling post-STEMI.
Copyright © 2021. Published by Elsevier España, S.L.U.
Datos de la publicación
- ISSN/ISSNe:
- 1885-5857, 1579-2242
- Tipo:
- Article
- Páginas:
- 384-391
- PubMed:
- 34045168
REVISTA ESPANOLA DE CARDIOLOGIA Elsevier Doyma
Citas Recibidas en Web of Science: 4
Documentos
Filiaciones
Keywords
- Cardiac magnetic resonance; Epithelial cell adhesion molecule; Infarto agudo de miocardio con elevación del segmento ST; Microvascular obstruction; Obstrucción microvascular; Resonancia magnética cardiaca; ST-segment elevation myocardial infarction
Proyectos y Estudios Clínicos
Un estudio multidisciplinar para avanzar en el entendimiento de los mecanismos básicos y la exploración de nuevas oportunidades terapéuticas en el infarto agudo de miocardio. Foco en los factores VEGF-A165b y ST2.
Investigador Principal: CÉSAR RIOS NAVARRO
FI18/00320 . INSTITUTO SALUD CARLOS III . 2019
Resolution of microvascular obstruction after myocardial infarction. A multidisciplinary approach to assess the structural and clinical consequences and to evaluate new therapeutic options.
Investigador Principal: VICENT BODÍ PERIS
PI20/00637 . INSTITUTO SALUD CARLOS III . 2021
Cita
EpCAM and microvascular obstruction in patients with STEMI: a cardiac magnetic resonance study. Rios C, Gavara J, Nunez J, Revuelta E, Monmeneu JV, Lopez MP, de Dios E et al. REVISTA ESPANOLA DE CARDIOLOGIA. 2022 mayo 01. 75 (5):384-391. DOI:10.1016/j.rec.2021.04.006. PMID:34045168.
