Portal de investigación
Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Farinas, Fernando
- Abanades, Sergio
- de la Cruz-Merino, Luis
- Alvaro Naranjo, Tomas
Grupos y Plataformas de I+D+i
Abstract
A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered metabolism and energetic dysfunction, which can shed light on pathophysiological mechanisms. Cancer is now considered a heterogeneous ecosystem, formed by tumor cells and the microenvironment, which is molecularly, phenotypically, and metabolically reprogrammable. A wealth of evidence confirms metabolic reprogramming activity as the minimum common denominator of cancer, grouping together a wide variety of aberrations that can affect any of the different metabolic pathways involved in cell physiology. This forms the basis for a new proposed classification of cancer according to the altered metabolic pathway(s) and degree of energy dysfunction. Enhanced understanding of the metabolic reprogramming pathways of fatty acids, amino acids, carbohydrates, hypoxia, and acidosis can bring about new therapeutic intervention possibilities from a metabolic perspective of cancer.
Datos de la publicación
- ISSN/ISSNe:
- 2218-1989, 2218-1989
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 33922558
Metabolites Multidisciplinary Digital Publishing Institute (MDPI)
Citas Recibidas en Web of Science: 11
Documentos
Filiaciones
Keywords
- tumor ecosystem; tumor microenvironment; tumor reprogramming
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: ROSA NOGUERA SALVA
CB16/12/00484 . INSTITUTO SALUD CARLOS III
Neuroblastoma: estrategias mecanoterapéuticas basadas en modelos 3D y tumores derivados de pacientes con microambiente rico en vitronectina
Investigador Principal: ROSA NOGUERA SALVA
PI20/01107 . INSTITUTO SALUD CARLOS III . 2021
Cita
Monferrer E,Vieco I,Lopez A,Farinas F,Abanades S,de la Cruz L,Noguera R,Alvaro T. Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction. Metabolites. 2021. 11. (5):264. IF:5,581. (2).
Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction. Monferrer E, Vieco I, Lopez A, Farinas F, Abanades S, de la Cruz L, Noguera R et al. Metabolites. 2021 abril 23. 11 (5):DOI:10.3390/metabo11050264. PMID:33922558.
