Portal de investigación
Circulating miR-30b-5p levels in plasma as a novel potential biomarker for early detection of breast cancer.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Constancio, V
- Salta, S
- Henrique, R
- Jeronimo, C
Grupos y Plataformas de I+D+i
Abstract
BACKGROUND: Recently, microRNAs have been demonstrated to be potential non-invasive biomarkers for diagnosis, prognosis assessment or prediction of response to treatment in cancer. In this study, we evaluate the potential of miR-30b-5p as a biomarker for early diagnosis of breast cancer (BC) in tissue and plasma. METHODS: Expression of miR-30b-5p was determined in a series of 112 BC and 40 normal breast tissues. Circulating miR-30b-5p levels in plasma samples were determined in a discovery cohort of 38 BC patients and 40 healthy donors and in a validation cohort of 83 BC patients and 83 healthy volunteers. miR-30b-5p expression was measured by quantitative real-time PCR and receiver operating characteristics curve analysis was carried out. RESULTS: The miR-30b-5p expression was significantly lower in BC tissue than in healthy breast samples. In contrast, circulating miR-30b-5p levels were significantly higher in BC patients compared with healthy donors. Furthermore, circulating miR-30b-5p levels were significantly higher in patients with positive axillary lymph node and de novo metastatic patients. Receiver operating characteristics curve analysis demonstrated a good diagnostic potential of miR-30b-5p to detect BC even at an early stage of the disease. CONCLUSION: Thus, we highlight the potential of miR-30b-5p as a non-invasive, fast, reproducible and cost-effective diagnostic biomarker of BC.
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 2059-7029, 2059-7029
- Tipo:
- Article
- Páginas:
- 100039-100039
- PubMed:
- 33477007
Esmo Open BMJ PUBLISHING GROUP
Citas Recibidas en Web of Science: 23
Documentos
Filiaciones
Keywords
- breast cancer; diagnosis; microRNA; plasma
Financiación
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Cita
Adam A,Garrido I,Simon S,Ortega B,Moragon S,Lameirinhas A,Constancio V,Salta S,Burgues O,Bermejo B,Henrique R,Lluch A,Jeronimo C,Eroles P,Cejalvo JM. Circulating miR-30b-5p levels in plasma as a novel potential biomarker for early detection of breast cancer. ESMO Open. 2021. 6. (1):p. 100039-100039. IF:6,883. (1).
Circulating miR-30b-5p levels in plasma as a novel potential biomarker for early detection of breast cancer. Adam A, Garrido I, Simon S, Ortega B, Moragon S, Lameirinhas A, Constancio V et al. Esmo Open. 2021 febrero 01. 6 (1):100039-100039. DOI:10.1016/j.esmoop.2020.100039. PMID:33477007.
