Ejection Fraction by Echocardiography for a Selective Use of Magnetic Resonance After Infarction.

Fecha de publicación: 01/12/2020 Fecha Ahead of Print: 10/12/2020

Autores de INCLIVA

• 

  Victor Marcos Garcés

  Autor

• Josep Gavara Doñate

  Autor

• J.vicente Monmeneu Menadas

  Autor

• César Rios Navarro

  Autor

• Elena Victoria De Dios Lluch

  Autor

• Nerea Júlia Pérez Solé

  Autor

• Joaquin Canoves Femenia

  Autor

• Jessika Ariadnna González D'gregorio

  Autor

• Gema Miñana Escriva

  Autor

• 

  Julio Nuñez Villota

  Autor

• 

  Rafael De La Espriella Juan

  Autor

• Enrique Santas Olmeda

  Autor

• David Moratal Perez

  Autor

• 

  Francisco Javier Chorro Gascó

  Autor

• 

  Vicent Bodí Peris

  Autor

Participantes ajenos a INCLIVA

• Lopez-Lereu, Maria P
• Valente, Filipa
• Lorenzatti, Daniel
• Rodriguez-Palomares, Jose F
• Ortiz-Perez, Jose T

Grupos y Plataformas de I+D+i

• Grupo de investigación en Cardiología Clínica

  

  Leading Researcher

  Juan Sanchis Fores

• Grupo de Investigación en Electrofisiología cardiaca experimental

  

  Leading Researcher

  Antonio M. Alberola Aguilar

• Grupo de Investigación en Insuficiencia Cardiaca

  

  Established Researcher

  Julio Nuñez Villota

• Grupo de Investigación Traslacional en Cardiopatía Isquémica

  

  Leading Researcher

  Vicent Bodí Peris

Abstract

Background Cardiac magnetic resonance (CMR) permits robust risk stratification of discharged ST-segment-elevation myocardial infarction patients, but its indiscriminate use in all cases is not feasible. We evaluated the utility of left ventricular ejection fraction (LVEF) by echocardiography for a selective use of CMR after ST-segment-elevation myocardial infarction. Methods Echocardiography and CMR were performed in 1119 patients discharged for ST-segment-elevation myocardial infarction included in a multicenter registry. The prognostic power of CMR beyond echocardiography-LVEF was assessed using adjusted C statistic, net reclassification improvement index, and integrated discrimination improvement index. Results During a 4.8-year median follow-up, 136 (12%) first major adverse cardiac events (MACE) occurred (47 cardiovascular deaths and 89 readmissions for acute heart failure). In the entire group, CMR-LVEF (but not echocardiography-LVEF) independently predicted MACE occurrence. The MACE rate significantly increased only in patients with CMR-LVEF<40% (=50%: 7%, 40%-49%: 9%, <40%: 27%, P<0.001). Most patients displayed echocardiography-LVEF=50% (629, 56%), and they had a low MACE rate (57/629, 9%). In patients with echocardiography-LVEF<50% (n=490, 44%), the MACE rate was also low in those with CMR-LVEF=40% (24/278, 9%) but significantly increased in patients with CMR-LVEF<40% (55/212, 26%; P<0.001). Compared with echocardiography-LVEF, CMR-LVEF significantly improved MACE prediction in the group of patients with echocardiography-LVEF<50% (C statistic, 0.80 versus 0.72; net reclassification improvement index, 0.73; integrated discrimination improvement index, 0.10) but not in those with echocardiography-LVEF=50% (C statistic 0.66 versus 0.66; net reclassification improvement index, 0.17; integrated discrimination improvement index, 0.01). Conclusions A straightforward strategy based on a selective use of CMR for risk prediction in ST-segment-elevation myocardial infarction patients with echocardiography-LVEF<50% can provide insights into patient care. The cost-effectiveness of this approach, as well as the direct implications in clinical management, should be further explored.

© 2020 American Heart Association, Inc

Keywords

• echocardiography; heart failure; myocardial infarction; magnetic resonance; prognosis; risk; ventricular ejection fraction