Therapeutic Potential of Extracellular Vesicles in Hypertension-Associated Kidney Disease.

Autores de INCLIVA

• Olga Martínez Arroyo

  Autor

• 

  Ana María Ortega Gutiérrez

  Autor

• 

  Josep Redón Mas

  Autor

• 

  Raquel Cortés Vergaz

  Autor

Grupos y Plataformas de I+D+i

• Grupo de Estudio de Riesgo Cardiometabólico y Renal

  

  Established Researcher

  Raquel Cortés Vergaz

Abstract

Hypertension-mediated organ damage frequently includes renal function decline in which several mechanisms are involved. The present review outlines the state of the art on extracellular vesicles in hypertension and hypertension-related renal damage. Emerging evidence indicates that extracellular vesicles, small vesicles secreted by most cell types and body fluids, are involved in cell-to-cell communication and are key players mediating biological processes such as inflammation, endothelial dysfunction or fibrosis, mechanisms present the onset and progression of hypertension-associated kidney disease. We address the potential use of extracellular vesicles as markers of hypertension-mediated kidney damage severity and their application as therapeutic agents in hypertension-associated renal damage. The capacity of exosomes to deliver a wide variety of cargos to the target cell efficiently makes them a potential drug delivery system for treatment of renal diseases.

Keywords

• exosomes; extracellular vesicles; hypertension; kidney diseases; therapeutics