Portal de investigación
Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Calabuig, Silvia
Abstract
Glioblastoma multiforme (GB) is one of the most aggressive tumors. Despite continuous efforts to improve its clinical management, there is still no strategy to avoid a rapid and fatal outcome. EGFR amplification is the most characteristic alteration of these tumors. Although effective therapy against it has not yet been found in GB, it may be central to classifying patients. We investigated somatic-copy number alterations (SCNA) by multiplex ligation-dependent probe amplification in a series of 137 GB, together with the detection of EGFRvIII and FISH analysis for EGFR amplification. Publicly available data from 604 patients were used as a validation cohort. We found statistical associations between EGFR amplification and/or EGFRvIII, and SCNA in CDKN2A, MSH6, MTAP and ADD3. Interestingly, we found that both EGFRvIII and losses on ADD3 were independent markers of bad prognosis (p = 0.028 and 0.014, respectively). Finally, we got an unsupervised hierarchical classification that differentiated three clusters of patients based on their genetic alterations. It offered a landscape of EGFR co-alterations that may improve the comprehension of the mechanisms underlying GB aggressiveness. Our findings can help in defining different genetic profiles, which is necessary to develop new and different approaches in the management of our patients.
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Datos de la publicación
- ISSN/ISSNe:
- 2073-4409, 2073-4409
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/cells9112429
- PubMed:
- 33172155
Cells MDPI
Citas Recibidas en Web of Science: 5
Documentos
Filiaciones
Keywords
- glioblastoma; IDH; ADD3; EGFR; survival; high throughout techniques; precision
Financiación
Proyectos y Estudios Clínicos
Papel de los microRNA en la regulación de las vías de señalización dependientes de EGFR en "gliomas astrocitarios de alto Grado". Desarrollo de un modelo poblacional de análisis poblacional y de distribución espacial en estas neoplasias
Investigador Principal: MIGUEL CERDA NICOLAS
PROMETEO/2011/083 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2011
Interacción de miRNA-200 y miRNA-138 en la infiltración y perfiles de MMI biomarcadores en el diagnostico, pronostico y terapéutico.
Investigador Principal: MIGUEL CERDA NICOLAS
PI14/01669 . INSTITUTO SALUD CARLOS III . 2015
Cita
Navarro L,San T,Megias J,Santonja N,Calabuig S,Munoz L,Roldan P,Cerda M,Lopez C. Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis. Cells. 2020. 9. (11):2429. IF:6,600. (2).
Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis. Navarro L, San T, Megias J, Santonja N, Calabuig S, Munoz L, Roldan P et al. Cells. 2020 noviembre 06. 9 (11):DOI:10.3390/cells9112429. PMID:33172155.
