Portal de investigación
Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19.
Fecha de publicación:
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Autores de INCLIVA
Participantes ajenos a INCLIVA
- Forteza, Maria J
Grupos y Plataformas de I+D+i
Abstract
This study aimed to assess the time course of circulating neutrophil and lymphocyte counts and their ratio (NLR) in ST-segment elevation myocardial infarction (STEMI) and coronavirus disease (COVID)-19 and explore their associations with clinical events and structural damage. Circulating neutrophil, lymphocyte and NLR were sequentially measured in 659 patients admitted for STEMI and in 103 COVID-19 patients. The dynamics detected in STEMI (within a few hours) were replicated in COVID-19 (within a few days). In both entities patients with events and with severe structural damage displayed higher neutrophil and lower lymphocyte counts. In both scenarios, higher maximum neutrophil and lower minimum lymphocyte counts were associated with more events and more severe organ damage. NLR was higher in STEMI and COVID-19 patients with the worst clinical and structural outcomes. A canonical deregulation of the immune response occurs in STEMI and COVID-19 patients. Boosted circulating innate (neutrophilia) and depressed circulating adaptive immunity (lymphopenia) is associated with more events and severe organ damage. A greater understanding of these critical illnesses is pivotal to explore novel alternative therapies.
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Datos de la publicación
- ISSN/ISSNe:
- 2077-0383, 2077-0383
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/jcm9113484
- PubMed:
- 33126723
Journal of Clinical Medicine MDPI
Citas Recibidas en Web of Science: 8
Documentos
Filiaciones
Keywords
- COVID-19; myocardial infarction; neutrophils; lymphocyte; prognosis; severity
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: VICENT BODÍ PERIS
CB16/11/00486 . INSTITUTO SALUD CARLOS III
Estudio multidisciplinar de la obstrucción microvascular y su reparación tras un infarto agudo de miocardio: de la arteria coronaria a la microcirculación. Foco en el factor VEGF-A165b (PI17/01836).
Investigador Principal: VICENT BODÍ PERIS
PI17/01836 . INSTITUTO SALUD CARLOS III . 2018
Resolution of microvascular obstruction after myocardial infarction. A multidisciplinary approach to assess the structural and clinical consequences and to evaluate new therapeutic options.
Investigador Principal: VICENT BODÍ PERIS
PI20/00637 . INSTITUTO SALUD CARLOS III . 2021
Cita
de Dios E,Rios C,Perez N,Gavara J,Marcos V,Rodriguez E,Carratala A,Forner MJ,Navarro J,Blasco ML,0000-0001-6638-5466,Signes J,Vila JM,Forteza MJ,Chorro FJ,Bodi V. Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19. J. Clin. Med. 2020. 9. (11):3484. IF:4,241. (1).
Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19. de Dios E, Rios C, Perez N, Gavara J, Marcos V, Rodriguez E, Carratala A et al. Journal of Clinical Medicine. 2020 octubre 28. 9 (11):DOI:10.3390/jcm9113484. PMID:33126723.
