Grupo de Investigación en Microbiología Molecular y Patogénesis Microbiana

Áreas de investigación

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  Oncología

  Coordinador:

  

  Andrés Cervantes Ruiperez

  HOSPITAL CLINICO UNIVERSITARIO DE VALENCIA

Líneas de investigación

1. Immunobiology of cytomegalovirus infection in patients undergoing allogeneic transplantation of hematopoietic precursors and hematological neoplasms - Cytomegalovirus, pathophysiology of infection and study of mortality in transplant patients - Study of genotypic resistance of cytomegalovirus using techniques of Next Generation Sequencing - Study of adaptive immunity T against cytomegalovirus in haematological patients
2. Viroma study, in particular the usefulness of monitoring anelloviruses, their quantity and distribution, as a tool to quantify the degree of immunosuppression or immunoreconstitution in allogeneic hematopoietic precursor transplantation (Alo-HSCT), in solid organ transplantation (SOT) and in autoimmune diseases treated with immunosuppressants - Study of Torque tenovirus as a surrogate marker of reconstitution or immunosuppression in allo-HSCT - Study of Torque tenovirus as a tool to guide the degree of immunosuppression in solid organ transplant patients - Study of the virome as a tool to generate a multifactorial score for prognostic purposes in different pathologies with an important immunological pathophysiogenic component
3. Immunobiology of SARS-CoV-2 infection - Post-vaccination B and T adaptive immunity in a high-risk population - Study of the virological characteristics of SARS-CoV-2 and its relationship with the clinical evolution of the patient with Covid-19
4. Design and evaluation of diagnostic algorithms, applicability and actions associated with the result of analytical techniques and development of new diagnostic strategies - Use of MALDI-TOF technology (Matrix-assisted laser desorption ionisation-time-of- fligh) for early identification and preliminary characterization of the resistotype in a blood sample from a patient with bacteremia - Use of MALDI-TOF (Matrix-assisted laser desorption ionisation-time-of-fligh) technology for early identification and preliminary characterization of the resistotype in urine samples in patients with suspected pyelonephritis
5. Molecular characterization of Neisseria gonorrhoeae
6. Analytical validation of diagnostic techniques - Study concordance between diagnostic techniques and linearity - Sensitivity, specificity, predictive values and robustness study
7. Clinical validation of diagnostic techniques - Clinical validation field studies of diagnostic techniques - Economic evaluations of diagnostic techniques and algorithms